Recent studies have revealed previously unknown mechanisms by which neutrophils contribute to tissue damage during acute myocardial infarction. This comprehensive review examines the latest findings regarding neutrophil-mediated injury, focusing on the role of neutrophil extracellular traps (NETs) and myeloperoxidase (MPO) in cardiac tissue damage. We discuss novel therapeutic approaches targeting these pathways and their potential clinical applications. The review also explores the temporal dynamics of neutrophil recruitment and activation in the infarcted myocardium, providing new insights into the inflammatory response following cardiac injury.
Neutrophils
Myocardial Infarction
Inflammation
NETs
MPO
DOI: 10.1038/s41569-024-0001-xPMID: 36789012
Myeloperoxidase as a Therapeutic Target in Cardiovascular Disease: A Randomized Clinical Trial
This double-blind, randomized controlled trial investigated the efficacy of a novel myeloperoxidase inhibitor in patients with acute coronary syndrome. The study enrolled 450 patients across 25 centers, demonstrating significant reduction in inflammatory markers and improved cardiac outcomes at 30 days. Secondary analyses revealed potential mechanistic insights into the role of myeloperoxidase in vascular inflammation and tissue damage. The results suggest a promising new therapeutic approach for treating cardiovascular diseases.